Publications

-Benedetta Ricci, Danika Sommer, Daymieri Narvaez, Ruqi Zhang, Jacob Geri, Sara Zaccara. Single residues within the YTHDF intrinsically disordered region control m6A-dependent mRNA decay

bioRxiv 2026.09.18.752746; doi: https://doi.org/10.64898/2026.09.18.752746

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-Murakami S, Olarerin-George AO, Liu JF, Zaccara S, Hawley B, Jaffrey SR. m(6)A alters ribosome dynamics to initiate mRNA degradation. Cell. 2025 Jul 10;188(14):3728-3743.e20. doi: 10.1016/j.cell.2025.04.020. Epub 2025 May 6. PubMed PMID: 40328256; PubMed Central PMCID: PMC12255529.

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-Elvira-Blázquez D, Fernández-Justel JM, Arcas A, Statello L, Goñi E, González J, Ricci B, Zaccara S, Raimondi I, Huarte M. YTHDC1 m(6)A-dependent and m(6)A-independent functions converge to preserve the DNA damage response. EMBO J. 2024 Aug;43(16):3494-3522. doi: 10.1038/s44318-024-00153-x. Epub 2024 Jul 1. PubMed PMID: 38951610; PubMed Central PMCID: PMC11329685.

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-Meriem Hadjer Hamadou, Laura Alunno, Tecla Venturelli, Samuel Valentini, Davide Dalfovo, 

Francesca Lorenzini, Alessia Mattivi, Vincenza Vigorito, Glenda Paola Grupelli, Alessandro Matte’, Pamela Gatto, Michael Pancher, Chiara Valentini, Veronica De Sanctis, Roberto Bertorelli, Virginie Marcel, Emilio Cusanelli, Stefano Freddi, Giovanni Bertalot, 

Sara Zaccara, Marina Mione, Luca L. Fava, Alessandro Romanel, Alberto Inga, A TranSNP in the DDIT4 mRNA can impact its translation efficiency and modulate p53-dependent responses in cancer cells

bioRxiv 2025.04.02.646512; doi: https://doi.org/10.1101/2025.04.02.646512

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-Zaccara S, Jaffrey SR. A Unified Model for the Function of YTHDF Proteins in Regulating m6A Modified mRNA. Cell. 2020 Jun 25;181(7):1582-1595.e18.

 

- Rizzotto D*, Zaccara S*, Rossi A, Galbraith MD, Andrysik Z, Pandey A, Sullivan KD, Quattrone A, Espinosa JM, Dassi E, Inga A. Nutlin-Induced Apoptosis Is Specified by a Translation Program Regulated by PCBP2 and DHX30. Cell Report. 2020 Mar 31;30(13):4355-4369.e6.

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- Zaccara S, Ries RJ, Jaffrey SR. Reading, writing and erasing mRNA methylation. Nat Rev Mol Cell Biol. 2019 Oct;20(10):608-624.

 

- Zaccara S, Tebaldi T, Pederiva C, Ciribilli Y, Bisio A, Inga A. p53-directed translational control can shape and expand the universe of p53 target genes. Cell Death Differ. 2014 Oct;21(10):1522-34.

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- Tebaldi T*, Zaccara S*, Alessandrini F, Bisio A, Ciribilli Y, Inga A. Whole-genome cartography of p53 response elements ranked on transactivation potential. BMC Genomics. 2015 Jun17;16(1):464. doi: 10.1186/s12864-015-1643-9.

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- Rizzotto D, Zaccara S, Rossi A, Dassi E, Inga A. Translation control can shape TP53- dependent cell fate. Mol Cell Oncol. 2020 Jun 23;7(5):1767483. doi: 10.1080/23723556.2020.1767483.

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- Ries RJ, Zaccara S, Klein P, Olarerin-George A, Namkoong S, Pickering BF, Patil DP, Kwak H, Lee JH, Jaffrey SR. m6A enhances the phase separation potential of mRNA. Nature. 2019 Jul;571(7765):424-428. doi: 10.1038/s41586-019-1374-1.

 

- Wu J, Zaccara S, Khuperkar D, Kim H, Tanenbaum ME, Jaffrey SR. Live imaging of

mRNA using RNA-stabilized fluorogenic proteins. Nature Methods. 2019 Sep;16(9):862-865.

 

- Vu LP*, Pickering BF*, Cheng Y*, Zaccara S, Nguyen D, Minuesa G, Chou T, Chow A, Saletore Y, MacKay M, Schulman J, Famulare C, Patel M, Klimek VM, Garrett-Bakelman FE, Melnick A, Carroll M, Mason CE, Jaffrey SR, Kharas MG. The N6-methyladenosine (m6A)- forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells. Nature Medicine. 2017 Nov;23(11):1369-1376.

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- Valentini S, Marchioretti C, Bisio A, Rossi A, Zaccara S, Romanel A, Inga A. TranSNPs: A class of functional SNPs affecting mRNA translation potential revealed by fraction-based allelic imbalance. iScience. 2021 Nov 27;24(12):103531. doi: 10.1016/j.isci.2021.103531.

 

- Boulias K*, Toczydłowska-Socha D*, Hawley BR*, Liberman N, Takashima K, Zaccara S, Guez T, Vasseur JJ, Debart F, Aravind L, Jaffrey SR, Greer EL. Identification of the m6Am -- Methyltransferase PCIF1 Reveals the Location and Functions of m6Am in the Transcriptome. Molecular Cell. 2019 Aug 8;75(3):631-643.e8.

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- Andrysik Z, Galbraith MD, Guarnieri AL, Zaccara S, Sullivan KD, Pandey A, MacBeth M, Inga A, Espinosa JM. Identification of a core TP53 transcriptional program with highly distributed tumor suppressive activity. Genome Research 2017 Oct;27(10):1645-1657.

 

- Bisio A, Z.mborszky J, Zaccara S, Lion M, Tebaldi T, Sharma V, Raimondi I, Alessandrini F, Ciribilli Y, Inga A. Cooperative interactions between p53 and NFκB enhance cell plasticity. Oncotarget. 2014 Dec 15;5(23):12111-25.

 

- Bustin SA, Benes V, Garson J, Hellemans J, Huggett J, Kubista M, Mueller R, Nolan T, Pfaffl MW, Shipley G, Wittwer CT, Schjerling P, Day PJ, Abreu M, Aguado B, Beaulieu JF, Beckers A, Bogaert S, Browne JA, Carrasco-Ramiro F, Ceelen L, Ciborowski K, Cornillie P, Sara Zaccara, Coulon S, Cuypers A, De Brouwer S, De Ceuninck L, De Craene J, De Naeyer H, De Spiegelaere W, Deckers K, Dheedene A, Durinck K, Ferreira-Teixeira M, Fieuw A, Gallup JM, Gonzalo-Flores S, Goossens K, Heindryckx F, Herring E, Hoenicka H, Icardi L, Jaggi R, Javad F, Karampelias M, Kibenge F, Kibenge M, Kumps C, Lambertz I, Lammens T, Markey A, Messiaen P, Mets E, Morais S, Mudarra-Rubio A, Nakiwala J, Nelis H, Olsvik PA, P.rez-Novo

C, Plusquin M, Remans T, Rihani A, Rodrigues-Santos P, Rondou P, Sanders R, Schmidt- Bleek K, Skovgaard K, Smeets K, Tabera L, Toegel S, Van Acker T, Van den Broeck W, Van der Meulen J, Van Gele M, Van Peer G, Van Poucke M, Van Roy N, Vergult S, Wauman J, Tshuikina-Wiklander M, Willems E, Zaccara S, Zeka F, Vandesompele J. The need for transparency and good practices in the qPCR literature. Nature Methods. 2013 Nov;10(11):1063-7.

 

- Pinzani P, Salvianti F, Zaccara S, Massi D, De Giorgi V, Pazzagli M, Orlando C. Circulating cell-free DNA in plasma of melanoma patients: qualitative and quantitative considerations. Clin Chim Acta. 2011 Nov 20;412(23-24):2141-5.