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Mystery solved: m6A is not selective

Updated: Feb 26, 2023

N6-methyladenosine (m6A), a widespread destabilizing mark on mRNA, is non-uniformly distributed across the transcriptome, yet the basis for its selective deposition have been a mystery for years.

After years trying to unravel why m6A deposition is selective, three research teams comes to exactly the same conclusion. They all notice m6A exclusion from splice junctions and discovered that this exclusion is mediated by the exon junction complex (EJC), potentially via physical occlusion.

What is the basic of m6A selectivity? Three research teams propose m6A deposition as rather not selective.

These findings open up new questions to the field: (1) Are there other "suppressors" that physically inhibit m6A deposition? (2) When is m6A deposition happening on an mRNA?

Here the links to the research articles:



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